2016

RUSSIAN JOURNAL OFCARDIOLOGY, 2016, 12 (140)

Address to the readers

Russ J Cardiol 2016, 12 (140): 5

CLINICAL MEDICINE NEWS

Clinical medicine updates: a review of international news

Russ J Cardiol 2016, 12 (140): 6

ORIGINAL ARTICLES

ASSESSMENT OF THE LEFT VENTRICLE SYSTOLIC FUNCTION WITH ULTRASOUND 2D-STRAIN TECHNOLOGY IN ARTERIAL HYPERTENSION

Khadzegova А. B.1, Yuschuk Е. N.1, Gabitova R. G.2, Sinitsina I. А.1, Ivanova S . V.1, Vasyuk Yu. А.1

Abstract

HEART HEMODYNAMICS IN EARLY PERIOD OF ACUTE ST ELEVATION ANTERIOR MYOCARDIAL INFARCTION BY 2D SPECKLE TRACKING ECHOCARDIOGRAPHY

Kercheva М. А.1, Ryabova Т. R.1, Ryabov V. V.1,2,3, Karpov R. S .1,2,3

Abstract

SCANNING TRANSMISSION ELECTRON MICROSCOPY FOR QUANTITATIVE MAPPING OF MACROELEMENT CONTENTS OF CARDIAC TISSUE

Komisov А. А.1, Osipova О. А.1, Shepel R. N.2, Drapkina О. М.3, Osipov P. G.1, Plaksina К. G.1, Malay N. V.1

Abstract

APPLICATION OF PREDICTION SCORES IN CLINICAL MEDICINE

Belyalov F. I.

Abstract

IMMEDIATE AND LONG-TERM RESULTS OF THE LEFT ATRIUM AURICLE OCCLUDER IMPLANTING IN ATRIAL FIBRILLATION

Shugushev Z. Kh.1,2, Rodionova L. V.1,2, Ganeeva О. N.3, Morozova N. V.2, Maksimkin D. А.1,2

Abstract

HIS LEFT BUNDLE BRANCH BLOCK — PREVALENCE AND RISK FACTORS FOR ELECTRICAL AND MECHANICAL DYSSYNCHRONY

Vozhdaeva Z. I.1, Sysuenkova E. V.1, Glukhova V. L.1, Duplyakov D. V.2,3, Khokhlunov S. M.2,3

Abstract

PREDICTION ROLE OF THE LEFT VENTRICLE REMODELLING IN ARTERIAL HYPERTENSION PATIENTS

Ivanova S. V., Vasyuk Yu. A., Shkolnik E. L., Khadzegova A. B., Sinitsina I. A.

Abstract

THE RELATION OF ATHEROGENIC OXIDATIVE-ANTIOXIDANT SHIFTS IN LOW DENSITY LIPOPROTEIDES WITH ADVERSE LONG-TERM PROGNOSIS IN MALES

Ragino Yu. I., Voevoda M. I., Malyutina S. K., Gafarov V. V., Shishkin S.V., Bogatyrev S.N., Scherbakova L.V., Polonskaya Ya. V.

Abstract

MARKERS OF ACCELERATED CONVERSION OF DIABETES MELLITUS IN VARIOUS CARDIOVASCULAR RISK PATIENTS

Mamedov M. N., Korneeva M. N.

Abstract

CLINICAL SIGNIFICANCE OF PROTEIN GROWTH AND INJURY FACTORS IN ACUTE CORONARY SYNDROME

Kayumova G. H.1,2, Razin V. A.2

Abstract

OUTPATIENT FOLLOW-UP OF THE LOWER EXTREMITIES ATHEROSCLEROSIS PATIENTS FROM CARDIOLOGIST POINT OF VIEW

Sumin A. N.1, Kosova М. А.2, Medvedeva Yu. D.2, Scheglova А. V.1, Makarov S. А.2, Artamonov G. V.1, Barbarash L. S.1

Abstract

ANALYSIS OF HEART RATE VARIABILITY AFTER EXERCISE WITH OSCILLATORY POLE

Ogata C. M.1, Abreu L. C.2, Vanderlei F. M.3, Navega M. T.1, Valenti V. E.1,4

Abstract

EXPERIMENTAL STUDY

FIRST TIME EXPERIMENTAL IMPLANTING OF LOCALLY DEVELOPED LEFT ATRIUM OCCLUDERS

Akhmedov S h. D.1, Batalov R. Е.1, Andreev S. L.1, Lugovsky V. А.1, Afanasiev S. А .1, Rebrova T . Yu.1, Vaizov V. Kh.1,
Rogovskaya Yu. V.1, Lotkov
А. I.2, Kudryashov А. N.3, Popov S. V.1

Abstract

CLINIC AND PHARMACOTHERAPY

CARDIOVASCULAR COMPLICATIONS RISK AND VASCULAR AGE DYNAMICS IN LONG-TERM TREATMENT OF ARTERIAL HYPERTENSION

Logacheva I. V.1, Baranova S. P.2, Safronova V. V.2, Ryazanova Т. А.1, Zajtsev D. S.2, Timonin D. V.2

Abstract

CLINICAL EFFECTIVENESS OF THE MODIFIED RELEASE TRIMETAZIDINE IN MICROVASCULAR ANGINA

Galin P. Yu., Gubanova T. G.

Abstract

HYPOLIPIDEMIC AND PLEIOTROPIC EFFICACY OF ROSUVASTATIN IN ARTERIAL HYPERTENSION PATIENTS OF HIGH CARDIOVASCULAR RISK IN LONG-TERM OUTPATIENT FOLLOW-UP

Mikhin V.P.1, Zhilyaeva Yu.А.1, Vorotyntseva V.V.2, Nebieridze D.V.3, Akhmedzhanov N.М .3, Vasil’eva D.А.1, Chernyatina М.А.1, Gromnatsky N.I.1

Abstract

OPINION ON A PROBLEM

MANAGEMENT OF PATIENT WITH ARTERIAL FIBRILLATION : WHAT `S NEW?

Napalkov D . A., Sokolova A. A.

Abstract

COMBINATION OF ACE INHIBITOR WITH AGONIST OF I1-IMIDAZOLINE RECEPTORS: NEW OPPORTUNITIES FOR ANTIHYPERTENSIVE THERAPY

Nedogoda S. V.

Abstract

LITERATURE REVIEW

THE ALTERNATIVE TOOLS FOR PREDICTION OF CARDIOVASCULAR RISK IN OBESITY: FOCUS ON ARTERIAL STIFFNESS

Druzhilov М. А.1, Druzhilova О. Yu.1, Otmakhov V. V.1, Kuznetsova Т. Yu.2

Abstract

INFORMATION

Russian Journal of Cardiology: contents for 2016

Russ J Cardiol 2016, 12 (140): 115-122

RUSSIAN JOURNAL OFCARDIOLOGY, 2016, 11 (139)

Address to the readers

Russ J Cardiol 2016, 11 (139): 5

CLINICAL MEDICINE NEWS

Clinical medicine updates: a review of international news

Russ J Cardiol 2016, 11 (139): 6

ORIGINAL ARTICLES

THE CONDITION OF DISTAL AORTA AFTER PROXIMAL RECONSTRUCTION FOR DISSECTION IN MARFAN SYNDROME

Chernyavskiy A. M., Lyashenko M. M., Sirota D. A., Alsov S. A., Khvan D. S.

Abstract

Marfan syndrome is a disease associated with high prevalence of aorta-related morbidity and mortality. Dissections and ruptures of thoracal aorta (ThAo) lead to decreased life duration in persons with Marfan syndrome with mediana at 30 year-old.

Aim. To study the changes of distal aorta and clinical outcomes after surgical treatment for proximal aorta dissection in Marfan syndrome.

Material and methods. In the SRICP, among patients operated for proximal aorta dissection, 14 were selected, who had histologically proven Marfan syndrome. They were followed-up.

Results. In the long-term follow-up after the intervention on thoracoabdominal aorta (TAAo) was required in 2 patients. Reasons for transforming of the distal aorta were the age of the disease onset (p=0,04), acute stage of dissection (p=0,02). Changes in TAAo developed during first months after primary intervention, as in several years.

Conclusion. Surgery for proximal dissections in Marfan syndrome patients is related to acceptable levels of morbidity and mortality in early and post-operation periods. Regular follow-up is required of such patients in post-operation period for on-time diagnostics and performing of secondary interventions.

Russ J Cardiol 2016, 11 (139): 7–11

http://dx.doi.org/10.15829/1560-4071-2016-11-7-11

Key words: Marfan syndrome, aorta dissection, aorta aneurysm, surgery, dysplasia.

Center for Surgery of Aorta, Coronary and Peripheral Arteries, E. N. Meshalkin Novosibirsk Scientific-Research Institute of Circulation Pathology, Novosibirsk, Russia.

LONG-TERM RESULTS OF THE VALVE-SAVING SURGERY IN MARFAN SYNDROME PATIENTS

Chernyavskiy A. M., Khvan D. S., Sirota D. A., Alsov S. A., Lyashenko М. М.

Abstract

The main causes of mortality and morbidity in Marfan syndrome patients are cardiovascular complications. The Bentall DeBono operation for long time has been a gold standard treatment for this pathology.

Aim. To present the obvious benefits of valve-saving surgery stimulating for saving of aorta valve (AoV) in dysplasia of connective tissue.

Material and methods. A single-center retrospective analysis was done, of the results of valve-saving operations on the aorta root. All Marfan syndrome patients were included, who had undergone valve-saving operation on AoV in 2007-2015 y. As the valve-saving operation the David method was used, operation of reimplanting of aorta root into prosthesis and supracoronary prosthesing of ascending aorta.

Results. Nine-year freedom from aortic regurgitation more 2 grade in long-term follow-up was 64%. As the a causes for development of aortic valve insufficiency were progressing degenerations of AoV. There were no cases of bleedings and endocarditis. Expected cumulative survival was 63%.

Conclusion. Valve-saving operations are applicable in patients with the syndrome of connective tissue dysplasia. However, the worth of valve-saving operations in Marfan syndrome is questionable. Taken the known data, the studies demanded, with more number of patients and longer follow-up.

Russ J Cardiol 2016, 11 (139): 12–15

http://dx.doi.org/10.15829/1560-4071-2016-11-12-15

Key words: aorta, aortic regurgitation, valve-saving surgery, Marfan syndrome.

Center for Surgery of Aorta, Coronary and Peripheral Arteries, E. N. Meshalkin Novosibirsk Scientific-Research Institute of Circulation Pathology, Novosibirsk, Russia.

CHOICE OF THE IMPLANTABLE SUPPORT RINGS IN CONNECTIVE TISSUE DYSPLASIA AND SEVERE MITRAL REGURGITATION

Bogachev-Prokofiev A. V., Afanasiev A. V., Zheleznev S. I., Nazarov V. M., Demin I. I., Astapov D. A., Karaskov A. M.

Abstract

Aim. To analyze the results of valve-securing surgery on mitral valve in connective tissue dysplasia.

Material and methods. From 2011 to 2014 y., totally 171 patient included, with isolated mitral regurgitation. Patients were randomized to 2 groups. Mean age in the Group D — ring, and Group C — flex, was 57 [42;65] and 54 [41;63] year old, respectively (p=0,092). Part of males was 69 and 67% in the groups, respectively.

Results. There were no cases of 30-day mortality. During 24 months of follow-up, in D ring and C flex groups, survival was 96,0±2,3% (95% CI 88,6-98,7%) and 94,3±2,8% (95% CI 85,5-97,9%), resp. (р=0,899); no re-operation — 97,0±2,1% (95% CI 88,4-99,3%) and 100%, resp. (р=0,044); no return of significant mitral regurgitation 80,8±6,5% (95% CI 64,0-90,3%) and 92,8±3,1% (95% CI 83,4-97,0%), resp. (р=0,002).

Conclusion. Application of flexible C flex rings in valve-securing operations makes it to achieve better results in middle-long-term post-operation period comparing to the usage of semi-hard support rings in patients with connective tissue dysplasia and severe mitral regurgitation.

Russ J Cardiol 2016, 11 (139): 16–21

http://dx.doi.org/10.15829/1560-4071-2016-11-16-21

Key words: mitral regurgitation, mitral insufficiency, connective tissue dysplasia.

E. N. Meshalkin Novosibirsk Scientific-Research Institute of Circulation Pathology, Novosibirsk, Russia.

ALDOSTERONE LEVELS AND HEART REMODELING IN MYOCARDIAL INFARCTION PATIENTS WITH NON-DIFFERENTIATED CONNECTIVE TISSUE DYSPLASIA

Miroshnichenko E. P., Ushakov A. V., Kubyshkin V. F.

Abstract

Aim. To assess the dynamics of aldosterone in blood serum and structurefunctional parameters of the heart in myocardial infarction patients, developed on the background of non-differentiated connective tissue dysplasia.

Material and methods. Totally, 90 patients included with Q-myocardial infarction with non-differentiated connective tissue dysplasia and without it. The controls were almost healthy persons without cardiovascular pathology, comparison group — patients with connective tissue dysplasia but not having cardiovascular pathology. Clinical and phenotypic assessment was done, echocardiography, aldosterone levels measurement in serum at dynamics of the infarction course.

Results. All patients, independent of existence of connective tissue dysplasia, showed aldosterone elevation at 1st day of infarction with further decrease to the level of controls or comparison in 28 days. In the group of infarction patients with non-differentiated connective tissue dysplasia there was significant enlargement of the left ventricle size, reduced pumping function with tendency to less prominent myocardial mass index increase comparing with those not having dysplasia.

Conclusion. Presence of non-differentiated connective tissue dysplasia does not influence aldosterone levels and their dynamics in myocardial infarction, but is associated with adverse type of postinfarction remodeling of the heart presenting with the left ventricle dilatation and decrease of its pumping function.

Russ J Cardiol 2016, 11 (139): 22–26

http://dx.doi.org/10.15829/1560-4071-2016-11-22-26

Key words: myocardial infarction, undifferentiated connective tissue dysplasia, aldosterone, postinfarction remodeling of heart.

S. I. Georgievsky Medical Academy, V. I. Vernadsky Crimean Federal University, Simferopol, Russia.

AN INDIVIDUALIZED RISK ASSESSMENT OF SUDDEN CARDIAC DEATH IN DILATION CARDIOMYOPATHY PATIENTS

Vaykhanskaya T. G.1, Sivitskaya L. N.2, Kurushko Т. V.1, Danilenko N. G.2, Melnikova О. P.1, Frolov А. V.1

Abstract

Search for effective methods of risk stratification in patients with higher risk of lifethreatening ventricular tachyarrhythmias (VTA) and sudden cardiac death is important task for applied healthcare and a priority scientific field.

Aim. To invent a mathematic model and algorithm of individualized risk assessment for sudden cardiac death (SCD) in dilation cardiomyopathy patients (DCMP).

Material and methods. Totally, 165 patients included, with verified DCMP (mean age 49,2±11,5 y; 135/81,8% males; NYHA class 2,67±0,45; LV ejection fraction 26,7±10,1%; follow-up 46,7±12,5 months). With an original software “Intecard 7”, with the data of 7-minute ECG-12 registration, we evaluated markers of electrical instability of myocardium — microvoltage alternans of T-waves (mATW), turbulence of cardiac rhythm (TCR), intervals QT and JT dispersion, acceleration and deceleration of cardiac rhythm. As primary endpoints for multifactorial Cox-analysis we used sustained ventricular tachicardia (VT) or ventricular fibrillation, shocks of implanted devices and documented SCD. We analyzed clinical, electrocardiographic, echocardiographic data and results of molecular-genetic study of lamin A/C gene (LMNA).

Results. As result of multifactor regression analysis we found 2 cumulative independent predictors (HR 5,23; 95% CI 1,45-16,9; р=0,013) of life-threatening VTA events in DCMP patients: paroxysms of non-sustained VT (≥5 ventricular complexes with HR ≥150 bpm) and changes in LMNA gene (missense mutations and polymorhpism of 10 exon of rs4641). With binary logit-regression analysis of independent risk factors (VES, sVT, mATW, TCR, JTd and GLS LV) we built-up a model of binary regression (F=31,2; χ2=143,2; p=0,0000) and developed an algorithm of SCD risk evaluation that make it to classify with high prediction power up to 93,9%, cases of DCMP (OR 470; sensitivity 80,8%, specificity 99,1%).

Conclusion. The invented algorithm of SCD risk is non-ivasive, individualized, easily applicable and interpretable technology that makes it to stratify patients with higher risk of life-threatening VTA with standard clinical and instrumental methods of investigation (ECG, EchoCG, Holter ECG). Implementation of the oroginal risk-stratification model makes it to optimize tactics of DCMP patients treatment and strategy of selection of potential candidates for cardioverter-defibrillator implanting for primary SCD prevention.

Russ J Cardiol 2016, 11 (139): 27–35

http://dx.doi.org/10.15829/1560-4071-2016-11-27-35

Key words: sudden cardiac death, dilation cardiomyopathy, markers of electrical instability of myocardium, lamin A/C genes mutation, risk stratification.

1 SI Republic Scientific-Practical Center of Cardiology, Minsk; 2SSI Institute of Genetics and Cytology of National Science Academy of Belarus, Minsk, Belarus.

DIAGNOSTIC SIGNIFICANCE OF NOVEL MARKERS FOR ASSESSMENT OF MYOCARDIUM CONDITION IN OBSTRUCTIVE DIFFUSE-GENERALIZED FORM OF HYPERTROPHIC CARDIOMYOPATHY

Frolova Yu. V.1, Dymova O. V.1, Babaev М. А.1, Kim S. Yu.1, Van Е. Yu.1, Sinitsin V. Е.2, Mershina Е. А.2, Dzemeshkevich S. L.1

Abstract

Aim. To evaluate informativity and relation of changes of galectin-3 (G3) and natriuretic brain peptide (BNP) in diagnostics of myocardium dysfunctions during analysis of surgical intervention in HCMP patients.

Material and methods. An analysis is presented, of 30 patients with diffusegeneralized type of hypertrophic cardiomyopathy (HCMP) (16 females and 14 males, mean age 53,7±2,8 y. o.), who during the time from 2009 to may 2016 in V. B. Petrovskiy Russian National Research Centre of Surgery, underwent the operation of extended myectomy. Before and after operation all patients underwent laboratory tests with measurement of the levels of BNP and G3 in serum, echocardiography, MRI/MSCT of the heart. Operations were done on-pump and pharmaco-cold cardioplegy.

Results. In transthoracal echocardiography there was significant decrease revealed, of interventricular septum thickness and gradient of ascending LV tractus, and nonsignificant enlargement of LV cavity during systole. In analysis of i. v. contrast MRI/MSCT of the heart in 26 patients there was non-significant increase of LV cavity during systole and decrease of LV mass in diastole. In analysis of serum BNP level as an important marker of clinical course and treatment efficacy, there was significant decrease of the values comparing to baseline in pre-operation period.

Conclusion. The extended myectomy surgery with parietal resection of papillary muscles makes it to reach good effect on an interventricular pressure gradient elimination in the space of whole ascending tractus of the left ventricle. Comparing to BNP that make it possible to evaluate the effectiveness of treatment, G3 is not so effective in diagnostics and there is yet no convincing evidence to confirm the value of G3 concentration in blood as an instrument that can be applied in monitoring of surgery effect.

Russ J Cardiol 2016, 11 (139): 36–39

http://dx.doi.org/10.15829/1560-4071-2016-11-36-39

Key words: diffuse-generalized form of DCMP, extended myectomy, fibrosis, brain natriuretic peptide, galectin-3.

1 V. B. Petrovskiy Russian National Research Centre of Surgery, Moscow; 2Treatment and Rehabilitation Center of the Ministry of Health, Moscow, Russia.

EFFICACY AND SAFETY OF SINGLE STAGE ENDOVASCULAR INTERVENTIONS WITH TRANSCATHETER IMPLANTING OF AORTIC VALVE

Kochkina K.V.1, Kochkina Т.А.1, Mashtakova О.B.1, Usik G.А.1, Myznikov А.V.1, Kulakov F.S.1, Malyshkin D.А.1, Sidorenko А.V.1, Evtyagin S.Е.1, Protopopov А.V.1,2

Abstract

Transcatheter implanting of aortic valve (TIAV) in critical aortic stenosis is a separate manipulation requiring thorough preparation. Among patients with critical aortic stenosis from a group of endovascular correction, there is a high prevalence of comorbid atherosclerotic lesions in coronary, carotid arteries, and other pathologies, manageable only interventionally.

Aim. To assess the efficacy and safety of single-moment performing of TIAV and additional endovascular interventions.

Material and methods. From the year 2011, in our clinic endovascular implanting of aortic valve was done for 125 patients with aortic valve dysfunction, in 51% (64 patients) had coronary, renal and carotid arteries lesion, aneurysmatic dilation of abdominal aorta. In 31 (48%) cases together with endovascular valve placement additionally endovascular interventions were done.

Results. Technical success was reached in all 125 cases. In-patient mortality from all causes was 7.2% (9 patients), with no significant difference between combination treatment group and other patients. In 2 cases there was stenting done, of coronary and carotid arteries (with 1 case of coronary, carotid and renal arteries), as single step. In one patient there was endovascular prevention done of ischemic complications of permanent atrial fibrillation by implanting of the system Watchman (Boston Scientific, USA) and stenting of coronary arteries; in one case a single step endoprosthesing of abdominal aorta was done and coronary stenting. In concomitant interventions group there was no myocardial infarction and no significant difference in cerebrovascular events between groups.

Conclusion. TIAV can be followed by single step addition of endovascular procedures if the surgical team and clinics has good experience, and with thorough planning of operation and post-surgery period.

Russ J Cardiol 2016, 11 (139): 41–46

http://dx.doi.org/10.15829/1560-4071-2016-11-41-46

Key words: concomitant interventions, transcatheter implanting of aortic valve.

1 Regional Clinical Hospital, Krasnoyarsk; 2V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russia.

RESULTS OF THE ARC AND ASCENDING AORTA PROSTHETIC REPLACEMENT UNDER DIFFERENT BRAIN PROTECTION CONDITIONS

Kamenskaya O. V., Klinkova A. S., Chernyavskiy A. M., Lomivorotov V. V., Karaskov A. M.

Abstract

Aim. To evaluate the results of prosthetic replacement of ascending aorta and the arc, according to the methods of brain protection.

Material and methods. Totally, 63 patients included, 52 (42-60) year old with DeBakey type I chronic dissection. Group 1 (n=32) — with the method of antegrade brain perfusion (AP) within artificial circulation (AC) and hypothermia (23-24º C); group 2 (n=31) with retrograde perfusion (RP) within AC and profound hypothermia (18º C). With the cerebral oxymetry the frontal lobe oxygen supply was measured (rSO2, %) during the operation. Questionnaire SF-36 was in use for life quality assessment before and late after operation.

Results. In the group 1 the rSO2 during AC reduced less than 10% from baseline, and in the group 2 values of rSO2 reduced by more than 30%, (p<0,05). Neurological complications in group 1 were registered in 12,5% cases, in the group 2 — in 35,4% (p<0,05). Logistic regression showed that decrease of rSO2 during AC for more than 33% from baseline does raise the odds for neurological disorders development 5 times. Mental health parameter (MH) in long-term follow-up of operation was negatively correlated with the duration of AC (r=-0,46; p=0,003).

Conclusion. Antegrade perfusion of the brain under conditions of moderate hypothermia during reconstruction surgery of proxymal aorta demonstrated better cerebroprotection, which was showed by lower rate of neurological complications in early post-operation period comparing to patients after systemic hypothermic AC.

Russ J Cardiol 2016, 11 (139): 47–53

http://dx.doi.org/10.15829/1560-4071-2016-11-47-53

Key words: aorta prosthetic replacement, cerebral protection, neurological complications.

E. N. Meshalkin Novosibirsk Scientific-Research Institute of Circulation Pathology, Novosibirsk, Russia.

BONE METABOLISM MARKERS IN AORTIC STENOSIS AND THE ROLE OF VITAMIN D DEFICIENCY

Zhiduleva E. V., Irtyuga O. B., Murtazalieva P. M., Karonova T. L., Moiseeva O. M.

Abstract

Aortic stenosis (AS) is of the most prevalent acquired heart valve defects; the role calcium is serious in its development. One of the key mediators of calcium metabolism is vitamin D.

Aim. To reveal the relation of the sufficiency of vitamin D with mineral bone density (MBD) and other biomarkers of calcification in AS patients.

Material and methods. Totally, 89 patients studied, with severe AS (aortic valve flow velocity more than 4 m/s) at the age 40-76 year old. The controls were almost healthy participants, blood donors (n=31). All patients underwent 25(OH)D in serum measurement, of osteopontin, C-reactive protein and lipid profile, as bienergetic x-ray absorptiometry of lumbar spine and of proximal femur.

Results. According to the data of absorptiometry, there was no osteoporosis or osteopenia in AS patients. However, the pressure gradient on aortic valve was related with MBD and T-criteria value. Vitamin D deficiency was found in 46% of patients. Content of 25(OH)D in serum of AS patients was lower and did not differ between bi- and tricuspid aortic valve patients. There was higher level of osteopontin in AS patients comparing to the controls. Decrease of 25(OH)D was associated with the decrease of osteopontin and atherogenety coefficient. There was no relation of the gradient on aortic valve and the level of vitamin D sufficiency.

Conclusion. Vitamin D deficiency might impact pathogenesis of AS regardless the anatomic specifics of aortic valve. Its action probably is mediated by the regulation with proinflammatory cytokines, such as osteopontin.

Russ J Cardiol 2016, 11 (139): 54–59

http://dx.doi.org/10.15829/1560-4071-2016-11-54-59

Key words: aortic stenosis, vitamin D, osteopontin.

Federal Almazov North-West Medical Research Centre of the Ministry of Health, Saint-Petersburg, Russia.

PULMONARY ARTERIAL HYPERTENSION DIAGNOSTICS SPECIFICS IN SYSTEMIC SCLERODERMIA

Simakova M. A., Maslyansky A. L., Naymushin A. V., Klyaus N. A., Moiseeva O. M.

Abstract

Aim. Pulmonary arterial hypertension (PAH) in systemic sclerodermia patients (SSD) is associated with poorer outcomes. Aim of current study is to assess the prevalence of PAH associated with SSD, among patients with newly diagnosed pulmonary hypertension (PH), included to the registry of Federal Almazov North-West Medical Research Centre and to conduct the analysis of applicability of the algorithms for earlier diagnostics of PH in SSD patients.

Material and methods. To comparative analysis we included patients with idiopathic PAH (iPAH) and PAH associated with SSD (SSD-PAH). All patients underwent thorough echocardiographic test (EchoCG), 6-minute walking test (6WT), spirometry. To confirm the diagnosis of PAH we applied the right chambers catheterization (RCC).

Results. Totally, 33 SSD patients included complaining on dyspnea, of those 14 had verified PAH and were taking specific treatment. With PHAROS algorithm we were able to separate additional risk subgroup of 6 patients for further study. Among participants, iPAH had 44%, and SSD-PAH — 11%. Most patients in both groups had III-IV FC (WHO) of PH: 55% of iPAH and 75% of PAH-SSD. In SSD patients there were lower values of the right ventricle systolic function by EchoCG [FAC=26±7% (р=0,028); TAPSE=15±3 mm (р=0,027); TAS’V=9±2 cm/s (р=0,023)]; values of lung diffusion capacity (DLco): 46±14% vs 62±16% in iPAH group (р=0,001) and distance of 6WT: 326±105 m vs 383±106 m (р=0,041). This data correlates with foreign registers and witness serious prognosis in PAH-SSD.

Conclusion. Our study demonstrated significance of novel algorithms development for earlier diagnostics of PAH and start of specific treatment according to severity of prognosis of SSD-PAH patients. Current guidelines for PAH diagnostics use DETECT algorithm as recommended for application in patients with SSD lasting for more than 3 years and DLco below 60%. We demonstrated the worth of inclusion in investigation algorithm for SSD the additional echocardiographic criteria for PH to increase specificity.

Russ J Cardiol 2016, 11 (139): 60–65

http://dx.doi.org/10.15829/1560-4071-2016-11-60-65

Key words: pulmonary hypertension, systemic sclerodermia, PAH.

Federal Almazov North-West Medical Research Centre of the Ministry of Health, Saint Petersburg, Russia.

BIOCHEMICAL MARKERS OF BONE TISSUE METABOLISM INFLUENCE ON VULNERABILITY OF ATHEROSCLEROTIC LESIONS

Polonskaya Ya. V.1, Kashtanova E. V.1,3, Murashov I. S.2, Volkov А. М.2, Chernyavskiy А. М.2, Ragino Yu. I.1

Abstract

Aim. To assess some of biochemical markers of bone tissue metabolism, in vessel wall in males with coronary atherosclerosis; to evaluate the influence of these markers on vulnerability of atherosclerotic lesion and to figure out the specifics of their spread among unstable plaques of various kinds.

Material and methods. Totally, 65 males included at the age 46-79 y. o., admitted to the Clinics of E. N. Meshalkin Novosibirsk Scientific-Research Institute of Circulation Pathology for coronary bypass surgery. During operation, an endarterectomy was performed of coronary arteries. Each specimen of endarterectomy was symmetrically divided to fragments for histological and biochemical studies. By the results of histological analysis, in 193 specimens we found: 19 fragments of intact intima, 102 stable, 72 unstable plaques. Then the types of unstable plaques were established: 1) lipids’; 2) inflammatory-erosive; 3) distrophic-necrotic. In homogenates of the fragments we assessed: osteoprotegerin, calcitonin, osteocalcin, cholesterol. Statistics was done with SPSS (13.0).

Results. By the results of the performed histology, in unstable plaques there was higher level of calcification comparing to stable plaques. Biochemical studies showed increased levels of calcitonin and osteocalcin. If to assess the diverse types of unstable plaques, the highest level of these parameters was found in distrophic-necrotic plaques; lowest amount of calcitonin and osteocalcin was found in inflammatory-erosive type. Content of cholesterol in stable and unstable atherosclerotic lesions was about 4 times higher (p<0,01) in comparison with intact intima. Relation of cholesterol with calcitonin and osteocalcin was found, as well.

Conclusion. The data shows that increased osteoprotegerin aids the stabilization of lesion, and calcitonin and osteocalcin might be markers of plaque instability, caused by increased calcification.

Russ J Cardiol 2016, 11 (139): 66–69

http://dx.doi.org/10.15829/1560-4071-2016-11-66-69

Key words: osteoprotegerin, calcitonin, osteocalcin, cholesterol, atherosclerotic plaque.

1 Scientific-Research Institute of Therapy and Prevention Medicine, Novosibirsk; 2E.N. Meshalkin Novosibirsk Scientific-Research Institute of Circulation Pathology, Novosibirsk; 3Novosibirsk State Technical University, Novosibirsk, Russia.

METHODS OF TREATMENT

RADIOFREQUENCY DENERVATION OF PULMONARY ARTERY IN SURGERY OF DYSPLASTIC MITRAL VALVE DEFECTS WITH SEVERE PULMONARY HYPERTENSION

Bogachev-Prokofiev A. V., Afanasiev A. V., Zheleznev S. I., Demidov D. P., Nazarov V. M., Demin I. I., Astapov D. A., Karaskov A. M.

Abstract

Pulmonary hypertension is an increase of pulmonary artery mean pressure for more than 25 mmHg at rest, measured by direct tensometry, and it includes a broad spectrum of diseases. Mechanisms of pulmonary hypertension are a connection of diverse vicious circles determining chronic progression of the disease, progradient worsening of patient’s condition and serious decline in life quality, and premature death. Severe pulmonary hypertension significantly raises risk of perioperation mortality and closely correlates with long-term survival. We propose an original technics of pulmonary artery denervation during one-stage cardiosurgical interventions, that confirmed its safety. Radiofrequency ablation of pulmonary artery in patients with dysplasia of connective tissue and high combined (precapillary and postcapillary) pulmonary hypertension, undergoing surgery for severe sympthomatic mitral insufficiency, is an effective procedure. An assessment is needed for short- and long-term results. Further studies will make it to know, whether the achieved hemodynamical benefits do turn to better clinical outcomes.

Russ J Cardiol 2016, 11 (139): 70–72

http://dx.doi.org/10.15829/1560-4071-2016-11-70-72

Key words: pulmonary hypertension, mitral insufficiency, connective tissue dysplasia.

E. N. Meshalkin Novosibirsk Scientific-Research Institute of Circulation Pathology, Novosibirsk, Russia.

LITERATURE REVIEWS

“VALVE-IN-VALVE” REPROSTHESING OF CARDIAC ARTIFICIAL VALVES

Klyshnikov R. Yu., Ovcharenko E. A., Kudryavtseva Yu. A., Barbarash L. S.

Abstract

Recently, the number of cardiac surgery in the world and particularly in Russia is raising, especially with utilization of biological prostheses; it is related to average population ageing too. Main disadvantage of such devices is restricted time period of work due to degrading of biomaterials, which demands additional surgery in longterm period (5-10 years). The technology of alternative reimplantation of bioprosthesis by method “prosthesis-into-prosthesis” using transcatheter low invasive devices is the most promising solution for the mortality risk reduction from operations on replacement of failing prosthesis. Current review includes an analysis of clinical results of application of that methodology for correction of acquired defects of aortic, mitral, tricuspid valves, and pulmonary artery valve. The results that are described, witness increasing interest of the world society in methodic as “prosthesis-into-prosthesis”, presenting via attempts for systematization and structuring of the interventions results. However complications that occur, risk and procedure restrictions significantly slow wider spread of the method application.

Russ J Cardiol 2016, 11 (139): 73–80

http://dx.doi.org/10.15829/1560-4071-2016-11-73-80

Key words: cardiac valve, transcatheter, low-invasive, prosthesis failure.

Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russia.

MITRAL VALVE PATHOLOGY IN CONNECTIVE TISSUE DYSPLASIA

Bogachev-Prokofiev A. V., Afanasiev A. V., Zhuravleva I. Yu., Demidov D. P., Zheleznev S. I., Malakhova O. Yu., Syrtseva Ya. V., Karaskov A. M.

Abstract

Recently, the main cause of mortality and disability in the world are cardiovascular diseases. By the data from autopsies, valve defects have 4-7% prevalence, and most common are mitral valve defects. Valve prolapse is caused by in-born defect of connective tissue development. Reconstruction surgery continue becoming more common in mitral regurgitation (MR) correction and is more preferable than the valve replacement. Regardless the long history of successful management of MR, official data from most world cardiosurgery centers shows than reconstruction operations are done just in 10-20% cases. Issues on the improvement of the management of patients with connective tissue dysplasia are still open. There is enough literature on laboratory and experimental studies showing benefits and disadvantages of one or other methods, but there are no large clinical trials with sufficient evidence, to confirm or stronly deny differences in clinical outcomes depending on the selection of one or other method.

Russ J Cardiol 2016, 11 (139): 81–86

http://dx.doi.org/10.15829/1560-4071-2016-11-81-86

Key words: mitral valve, connective tissue dysplasia, acquired valve defects.

E. N. Meshalkin Novosibirsk Scientific-Research Institute of Circulation Pathology, Novosibirsk, Russia.

CLINICAL CASES

CARDIAC MYXOMA — CHALLENGE IN DIAGNOSTICS

Fursov А.А.1, Gordeev V.V.1,3, Demko I.V.2,3, Gordeeva N.V.2,3, Kraposhina А.Yu.2, Solovyova I.А.2,3, Mosina V.А.2,3, Sobko Е.А.2,3

Abstract

Clinical presentation of myxomas is diverse, so it is not easy to diagnose this pathology even with available modern instrumental methods. With its “natural” course this pathology is associated with poor outcome, most patients die in several years from the first clinical signs onset.

Russ J Cardiol 2016, 11 (139): 87–89

http://dx.doi.org/10.15829/1560-4071-2016-11-87-89

Key words: myxoma, heart, clinical case.

1 Federal Center of Cardiovascular Surgery, Krasnoyarsk; 2V. F. Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk; 3 Regional Clinical Hospital, Krasnoyarsk, Russia.

AN ORPHAN PHENOTYPE OF CARDIOGENITAL LAMINOPATHY — MALOUF SYNDROME

Vaykhanskaya T. G.1, Sivitskaya L. N.2, Danilenko N. G.2, Kurushko Т. V.1, Nizhnikova О. G.1, Davydenko О. G.2

Abstract

Recent decades significantly increased the spectrum of monogenic diseases associated with mutations in the gene of lamin A/C (LMNA), that codes the proteins group performing important functions in the nucleus. This pathology presents with diverse systemic tissue involvement. Mutations of the gene LMNA are the cause of more than ten different inherited disorders — laminopathies. In clinical practice, there are cardial phenotypes common, i. e. dilation cardiomyopathy (DCMP), skeletal-muscular dystrophies (Emery-Dreifuss dystrophy, inherited and limbleveled) and more rare forms — lipodystrophies, progeroid phenotypes (acromandibular dysplasia, Hutchinson-Gilford progeria, atypical Werner syndrome), Malouf syndrome. Malouf syndrome, known nowadays as cardiogenital syndrome, is rare inborn pathology with DCMP phenotype and ovarial dysgenesis (females) or primary testicular failure (males), with cognitive delay and variety of skeletal abnormalities (usually facial dysmorphism and marfanoid signs). The arcticle presents a clinical case of female patient with primary amenorrhea, hypogonadism, DCMP, cognitive deficiency, hypodeveloped secondary gender signs, body mass deficiency, and facial dysmorphism. Radiation, viral parotitis, autoimmunity and Turner syndrome were ruled out. Signs if bone dysplasia typical for mandibular-acral dysplasia are absent. Relatives of the 1st line are normal. With sequencing method, we searched for mutations in the gene LMNA, but there were no mutations. Results make it to suggest that pathogenetic mechanisms of Malouf syndrome are not only of “lamin” nature but of other genetic causes too. The article also points on the key issues of diagnostics and treatment, presents differential criteria and clinical signs of an orphan disease.

Russ J Cardiol 2016, 11 (139): 90–94

http://dx.doi.org/10.15829/1560-4071-2016-11-90-94

Key words: lamin gene mutations А/С, dilation cardiomyopathy, hypergonadotropic hypogonadism.

1 Republic Scientific-Practical Center “Cardiology”, Laboratory for medical information technologies, Minsk; 2State Scientific Institution of genetics and cytology of the National Science Academy of Belarus, Laboratory of nonchromosome inheritance, Minsk, Belarus.

CASE OF PSEUDOCORONARY PRESENTATION OF MYOCARDITIS WITH ST SEGMENT ELEVATION

Gomboeva S. B.1,2, Ryabov V. V.1,2,3, Shelkovnikova Т. А.1, Usov V. Yu.1, Markov V. А.1,3, Karpov R. S.1,3

Abstract

Clinical case demonstrates the necessity for multimodal visualization of the heart in differential diagnostics of acute coronary syndrome with ST elevation in patients with non-obstruction coronary heart disease. This made possible to be sure on the diagnosis of pseudocoronary variant of myocarditis, to prescribe etiotropic and pathogenetic treatment. On-time diagnostics of alternative causes of chest pain may help to avoid unnecessary treatments related to acute myocardial infarction.

Russ J Cardiol 2016, 11 (139): 95–96

http://dx.doi.org/10.15829/1560-4071-2016-11-95-96

Key words: acute coronary syndrome, non-obstructive atherosclerosis, myocarditis, cardiac MRI.

1 RI Cardiology, Tomsk; 2National Research Tomsk State University, Tomsk; 3Siberian State Medical University (SSMU), Tomsk, Russia.

RUSSIAN JOURNAL OFCARDIOLOGY, 2016, 10 (138)

Address to the readers

Russ J Cardiol 2016, 10 (138): 5

CLINICAL MEDICINE NEWS

Clinical medicine updates: a review of international news

Russ J Cardiol 2016, 10 (138): 6

ORIGINAL ARTICLES

GENETICS IN CARDIOLOGY

REGULAR GENETIC COUNSELING AND DNA-DIAGNOSTICS OF MARFAN SYNDROME IN THE WORK OF FEDERAL SURGERY INSTITUTION

Rumyantseva V. A., Rogozhina Yu. A., Bukaeva A. A., Bazarov D . V., Charchyan E. R., Zaklyazminskaya E. V.

Abstract

MUTATION SPECTRUM OF THE GENE KCNQ1 IN RUSSIAN PATIENTS WITH LONG QT SYNDROME

Polyak M. E.1, Ivanova Е. А.2, Polyakov А. V.2, Zaklyazminskaya Е. V.1,3

Abstract

A CASE OF DNA-DIAGNOSTICS APPLICATION FOR ARRHYTHMOGENIC RIGHT VENTRICLE CARDIOMYOPATHY

Shestak A. G.1, Blagova O. V.2, Lutokhina Yu. A.2, Frolova Yu. V.1, Dzemeshkevich S. L.1, Zaklyazminskaya E. V.1,3

Abstract

FIRST RUSSIA-BASED STUDY OF POLYMORPHISM rs2200733 CHROMOSOME 4q25 ASSOCIATION WITH DEVELOPMENT OF THE LONE ATRIAL FIBRILLATION

Shulman V. A.1, Nikulina S. Yu.1, Aksyutina N. V.1, Poplavskaya Е. Е.1, Nazarov B. V.1, Maksimov V. N.2

Abstract

THE ROLE OF INTERLEUKIN-6 GENE IN DEVELOPMENT OF IDIOPATHIC SICK SINUS SYNDROME

Nikulina S. Yu.1, Marilovtseva O. V.1, Chernova А. А.1, Tretyakova S. S.1, Nikulin D. А.1, Maksimov V. N.2

Abstract

POLYMORPHISM OF THE INTERLEUKIN-6, INTERLEUKIN-10, SUPEROXIDE DISMUTASE AND ANGIOTENSIN CONVERTING ENZYME GENES, AND THE RISK OF ATRIAL FIBRILLATION AFTER CARDIOSURGERY

Rubanenko О. А.1,2, Fatenkov О. V.1, Khokhlunov S. М.1,2, Shavkunov S. А.3

Abstract

INFLUENCE OF COMBINED CARRIAGE OF LIPID TRANSPORTING SYSTEM GENES POLYMORPHISMS ON THE GRADE OF CORONARY ATHEROSCLEROSIS IN UNSTABLE ANGINA PATIENTS

Eshpulatov A. S., Hoshimov Sh. U., Shek A. B ., Kurbanov R. D .

Abstract

PROGNOSTIC SIGNIFICANCE OF MET235/235THR POLYMORPHISMS OF GENE AGT FOR DEVELOPMENT OF CARDIOVASCULAR DISORDERS IN PROFESSIONAL SPORTSMEN

Muzhenya D. V.1, Tuguz A. R.1, Ashkanova Т. М.2, Pshidatok А. R.2, Smolkov I. V.1, Shumilov D. S.1

Abstract

GENERAL WORKS

ASSOCIATION OF GLUCOSE WITH GENERAL AND CARDIOVASCULAR MORTALITY AMONG POPULATION FROM 55 YEARS AND OLDER

Imaeva A. E.1, Kapustina A. V.1, Smirnov D. А.1, Balanova Yu. А.1, Muromtseva G. А.1, Deev А. D.1, Shalnova S. А.1, Shkolnikova М. А.2, Shkolnikov V. М.3

Abstract

COMPARISON OF EFFECTIVENESS OF COMBINATION ANTIHYPERTENSION THERAPY IN WOMEN WITH ABDOMINAL OR GLUTEO-FEMORAL OBESITY

Skibitsky V. V.1, Skibitskaya S. V.2, Fendrikova A. V.1, Porodenko N. V.1

Abstract

SPECIFICS OF SUBFRACTIONAL SPECTRUM OF APOLIPOPROTEIN B RELATED LIPOPROTEINES IN CAROTID OR CORONARY ATHEROSCLEROSIS PATIENTS

Gavrilova N . E., Metelskaya V. A., Ozerova I. N ., Yarovaya E. B ., Boytsov S. A.

Abstract

INFLUENCE OF COVERT CARBOHYDRATE METABOLISM DISORDERS ON THE RISK OF KIDNEY FUNCTION DECLINE

Vatutin N. Т.1,2, Zinkovych М. I.1, Yakubenko Е. D.1

Abstract

CLINICAL OBSERVATION

DIAGNOSTICAL EXPLORATION ON THE DISEASE PRESENTED AS ACUTE CORONARY SYNDROME, AT THE AGE OF GENETICS. CLINICAL CASE

Krylova N . S.1,2, Poteshkina N . G.1,2, Demkina А. Е.2, Kovalevskaya Е. А.1,2, Lorenzo Monserrat Iglesias3, Diego Garsia3

Abstract

MYOCARDIAL INFARCTION AS TYPICAL PRESENTATION OF NONCOMPACTION CARDIOMYOPATHY

Blagova O. V., Nedostup A. V., Pavlenko E. V., Sedov V. P., Kogan E. A., Gagarina N . V., Mershina E. A., Sulimov V. A.

Abstract

NOONAN SYNDROME AS RESULT OF MUTATION p. S257L OF GENE RAF1: CLINICAL CASE AND REVIEW

Bukaeva А. А.1, Kotlukova N. P.2,3, Zaklyazminskaya Е. V.1,3

Abstract

TWO MUTATIONS CONCOMITANCE IN FEMALE PATIENT WITH ARRHYTHMIC TYPE OF NONCOMPACTION MYOCARDIUM SYNDROME

Polyak М. Е.1, Bukaeva А. А.1, Shestak А. G.1, Blagova О. V.2, Sveshnikov А. V.3, Lutokhina Yu. А.2, Nedostup А. V.2, Zaklyazminakaya Е. V.1

Abstract

CLINICAL CASE

EFFECTIVENESS OF THROMBOLYSIS BY NON-IMMUNOGENIC STAPHYLOKINASE IN PATIENT WITH ST-ELEVATION MYOCARDIAL INFARCTION

Vatutin N. T .1,2, Kostogryz V. B.1, Kostogryz А. I.3, Polyakova О. А.1, Ryabko Е. А.1, Stolika О. I.1, Zagoruyko А. N.2

Russ J Cardiol 2016, 10 (138): 105–106

http://dx.doi.org/10.15829/1560-4071-2016-10-105-106

Key words: cardiology, myocardial infarction, reperfusion.

1 V. K. Gusak Institute of Urgent and Recovery Surgery, Donetsk; 2M. Gorky Donetsk National Medical University, Donetsk; 3City Hospital №4, Donetsk, Ukraine.

RUSSIAN JOURNAL OFCARDIOLOGY, 2016, 9 (137)

Address to the readers

Russ J Cardiol 2016, 9 (137): 5

CLINICAL MEDICINE NEWS

Clinical medicine updates: a review of international news

Russ J Cardiol 2016, 9 (137): 6

ORIGINAL ARTICLES

LIFE QUALITY OF PERSONS WITH ARTERIAL HYPERTENSION IN RUSSIA — IS THERE RELATION TO TREATMENT? (BY DATA FROM POPULATIONAL STUDY ESSE-RF)

Balanova Yu. A., Kontsevaya A. V., Shalnova S. A., Deev A. D., Kapustina A. V., Evstifeeva S. E., Muromtseva G. A., Imaeva A. E ., Boytsov S. A.

Abstract

SPECIFICS OF ARTERIAL HYPERTENSION COURSE IN PATIENTS WITH AORTIC ATHEROSCLEROSIS COMPLICATED BY ACUTE THROMBOTIC OCCLUSION

Evsikov Е. М.1,2, Teplova N. V.1, Maytesian D. А.2, Sharipov R. А.2, Zhapueva М. Kh.1, Levchuk N. N.2, Kashirin V. V.2, Chervyakova G. А.2, Kurumlidu Е . G.1, Abduragimov S. А.1

Abstract

RESULTS OF BIODEGRADABLE VASCULAR ENDOPROSTHESES IMPLANTATION IN ISCHEMIC HEART DISEASE PATIENTS WITH TYPE 2 DIABETES

Shugushev Z. Kh.1,2, Maksimkin D. А.1,2, Vorob’eva Yu. S.1, Chepurnoj А. G.2, Veretnik G. I.1, Fajbushevich А. G.1

Abstract

SOMATIC COMORBIDITY AMONG MEN AND WOMEN WITH STABLE ANGINA

Mamedov M. N.1, Didigova R. T.2, Ugurchieva Z. O.2

Abstract

CLINIC AND PHARMACOTHERAPY

ANTIARRHYTHMIC ACTION OF CARDIOCYTOPROTECTORS IN TREATMENT OF ISCHEMIC HEART DISEASE WITH VENTRICULAR ARRHYTHMIAS

Ryngach E. A., Tatarinova A. A., Ryzhkova D. V., Budanova M. A., Treshkur T. V.

Abstract

FIXED COMBINATION OF RAMIPRIL AND HYDROCHLOROTHIAZIDE: TO WHOM AND WHAT FOR?

Nedogoda S. V.

Abstract

ACTUAL TOPICS

ISSUES OF MEDICAL SPECIALISTS EDUCATION. FOUNDATION OF INSTITUTE OF INDEPENDENT PROFESSIONAL EXPERTS

Sirotkina O. V., Ishchuk T. N., Parmon E. V., Shlyakhto E . V.

Abstract

“MEDICINE OF THE WHOLE PATIENT”: A MODERN PERUSAL OF CLASSICAL CLINICIAN’S TEXT

Taratukhin E. O., Nozdrachev D. I.

Abstract

LITERATURE REVIEWS

PATHOPHYSIOLOGY OF ACUTE HEART FAILURE. WHAT’S NEW?

Tereshchenko S. N., Zhirov I. V., Nasonova S. N., Nikolaeva O. A., Ledyakhova M. V.

Abstract

CARDIOVASCULAR PATIENT WITH STAGE 1-3 CHRONIC KIDNEY DISEASE: CONTEMPORARY CARDIONEPHROPROTECTION IN REAL CLINICAL PRACTICE

Tarlovskaya E. I.

Abstract

MECHANISMS OF CARDIOVASCULAR DISEASES DEVELOPMENT IN OBESITY AND INSULIN RESISTANCE: FOCUS ON ATHEROTHROMBOSIS

Shishkova V. N.

Abstract

PATIENT-CENTERED MEDICINE. A NEW REALITY

Taratukhin E. O.

Abstract

TELOMERE LENGTH AND ATHEROSCLEROSIS

Drapkina O. M., Shepel R. N.

Abstract

SYSTEMIC CARDIOVASCULAR OUTCOMES OF SLEEP RELATED BREATHING DISORDERS

Kallistov D. Yu.1, Romanov A. I.1, Novichkova N. I.2, Romanova Е. А.3

Abstract

RUSSIAN JOURNAL OFCARDIOLOGY, 2016, 8 (136)

Address to the readers

Russ J Cardiol 2016, 8 (136): 5

CLINICAL MEDICINE NEWS

Clinical medicine updates: a review of international news

Russ J Cardiol 2016, 8 (136): 6

EDITORIAL

CHRONIC HEART FAILURE IN RUSSIAN FEDERATION: WHAT DO WE KNOW AND WHAT TO DO

Fomin I. V.

Abstract

ORIGINAL ARTICLES

RELIABILITY AND DISCRIMINANT VALIDITY OF THE RUSSIAN VERSION OF EUROPEAN SELF-CARE BEHAVIOUR SCALE IN CHRONIC HEART FAILURE

Lopatin Yu. M.1,2, Grebennikova А. А.1,2, Begrambekova Yu. L.3

Abstract

SEGMENTAL ANALYSIS OF DIASTOLIC DYSFUNCTION OF THE LEFT VENTRICLE IN MYOCARDIAL POSTINFARCTION FOCAL CHANGES

Shvets D. A.1, Povetkin S. V.2

Abstract

ELECTRICAL INSTABILITY OF MYOCARDIUM IN INFARCTION PATIENTS AND ITS PROGNOSTIC SIGNIFICANCE

Galin P. Yu., Sermyagin D. V.

Abstract

PLACE OF VOLUMETRIC LOAD IN ASSESSMENT OF DIASTOLIC RESERVE OF THE LEFT VENTRICLE AND IN PREDICTION OF HEART FAILURE DEVELOPMENT FOR MYOCARDIAL INFARCTION PATIENTS

Beyshenkulov М. Т., Abdurashidova Т. Sh., Kaliev К. R., Toktosunova А. К., Tagaeva А. К.

Abstract

DYNAMICS OF HEMOSTASIS AND NEUTROPHIL FUNCTIONAL ACTIVITY CHANGES IN PATIENTS WITH VARIOUS SENSITIVITY TO ACETYLSALICYLIC ACID IN ACUTE MYOCARDIAL INFARCTION

Grinshtein I. Yu.1, Savchenko А. А.1,2, Grinshtein Yu. I.1, Shimokhina N. Yu.1, Petrova М. М.1, Gvozdev I. I.2

Abstract

MICROCIRCULATORY RESERVES AND TISSUE METABOLISM REACTIVITY IN VARIOUS STAGE ISCHEMIC CONGESTIVE HEART FAILURE

Klinkova A. S., Kamenskaya O. V.

Abstract

INFLUENCE OF PSYCHOEMOTIONAL DISORDERS ON THE EFFECTIVENESS OF EDUCATION AND ACTIVE OUTPATIENT CONTROL IN HEART FAILURE PATIENTS

Begrambekova Yu. L.1, Mareev V. Yu.1, Drobizhev M. Yu.2

Abstract

IMPACT OF THE RIGHT VENTRICLE DYSFUNCTION ON CHRONIC HEART FAILURE PRESENTATION IN PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY

Poteshkina N. G.1, Demkina А. Е.1, Krylova N. S.1, Kovalenskaya Е. А.2, Khashieva F. М.1

Abstract

RISK FACTORS AND PREDICTION OF MIOCARDIAL INFARCTION IN MALES OF DIFFERENT AGE

Suspitsina I. N., Sukmanova I. A.

Abstract

CORONARY REPERFUSION IN SENILE PATIENTS WITH ACUTE ST ELEVATION MYOCARDIAL INFARCTION

Vyshlov E. V.1,2

Abstract

CLINIC AND PHARMACOTHERAPY

RATIONALE FOR APPLICATION, AND BENEFITS OF TRIMETAZIDINE IN HEART FAILURE BY ITS INFLUENCE OF MYOCARDIUM METABOLISM

Lopatin Yu. M.1, Rosano Giuseppe M. K.2,3, Fragasso Gabriel4, Lopashchuk Gari D.5, Seferovich Petar M. 6, Goudac Louis Henrique V.7, Vinereanu Dragos8, Hamid Magdi Abdel9, Jourdain Patric10, Ponikovsky Petr 11#

Abstract

IVABRADINE IN PATIENTS WITH CHRONIC HEART FAILURE WITH REDUCED EJECTION FRACTION: NEW DATA FROM THE SHIFT MULTICENTER RANDOMIZED TRIAL

Tereshchenko S. N., Zirov I. V., Romanova N. V.

Abstract

OPINION ON A PROBLEM

MOLECULAR BIOMARKERS FOR DIAGNOSTICS, RISK STRATIFICATION AND PREDICTION OF CHRONIC HEART FAILURE

Medvedeva Е. А.1, Surkova Е. А.1,2, Limareva L. V.1, Shchukin Yu. V.1

Abstract

HYDRODYNAMIC FUNDAMENTALS FOR PHYSICAL-MATHEMATICAL MODEL OF MYOCARDIUM CIRCULATION

Milyukov V. E.1,2, Zharikova T . S.1

Abstract

CHRONIC HEART FAILURE OF ISCHEMIC ORIGIN: ROLE OF CHRONIC PULMONARY OBSTRUCTIVE DISEASE

Vatutin N. T .1,2, Smyrnova А. S.1,2, Gasendich Е. S.1

Abstract

CLINICAL CASES

A RARE CASE OF MYOCARDIAL INFARCTION IN CORONARY ARTERIES ECTASIA

Kukharchik G. А.1,2, Sorokin L. А.2, Koval I. N.2, Saraev G. B.2

Abstract

RUSSIAN JOURNAL OFCARDIOLOGY, 2016, 7 (135)

Address to the readers

Russ J Cardiol 2016, 7 (135): 4

CLINICAL GUIDELINES

2015 ESC GUIDELINES FOR THE MANAGEMENT OF PATIENTS WITH VENTRICULAR ARRHYTHMIAS AND THE PREVENTION OF SUDDEN CARDIAC DEATH

The Task Force for the Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death of the European Society of Cardiology (ESC)

Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC)

Russ J Cardiol 2016, 7 (135): 5–86

http://dx.doi.org/10.15829/1560-4071-2016-7-5-86

Key words: acute coronary syndrome, cardiac resynchronization therapy, cardiomyopathy, congenital heart disease, defibrillator, guidelines, heart failure, implantable cardioverter defibrillator, myocardial infarction, resuscitation, stable coronary artery disease, sudden cardiac death, tachycardia, valvular heart, disease, ventricular arrhythmia.

CLINICAL MEDICINE NEWS

Clinical medicine updates: a review of international news

Russ J Cardiol 2016, 7 (135): 87

ORIGINAL ARTICLES

FOCUS-GUIDED ENDOMYOCARDIAL BYOPSY IN DIAGNOSTICS OF ARRHYTHMOGENIC DYSPLASIA OF THE RIGHT VENTRICLE IN PATIENTS SCHEDULED FOR CATHETER ABLATION OF VENTRICULAR ARRHYTHMIAS

Simonova K. A., Mikhaylov E . N., Tatarsky R. B., Mitrofanova L. B., Lebedev D. S .

Abstract

CURRENT STATE OF THE HEART VALVES POSTOPERATION MANAGEMENT

Gorlova I. A., Omelchenko M. Yu., Kazantseva T. I., Nedoshivin A. O., Bondarenko B. B.

Abstract

RUSSIAN JOURNAL OFCARDIOLOGY, 2016, 6 (134)

Address to the readers

Russ J Cardiol 2016, 6 (134): 5

CLINICAL MEDICINE NEWS

Clinical medicine updates: a review of international news

Russ J Cardiol 2016, 6 (134): 6

EDITORIAL

NOSOLOGICALLY AND AGE-STRATIFIED MORTALITY STRUCTURE FROM CARDIOVASCULAR DISEASES IN THE YEARS 2006 AND 2014

Samorodskaya I. V.1, Starinskaya М. А.1, Semyonov V. Yu.2, Kakorina Е. P.3

Abstract

ORIGINAL ARTICLES

MORTALITY IN 55 YEARS AND OLDER POPULATION AND ITS RELATION WITH ISCHEMIC HEART DISEASE, TRADITIONAL RISK FACTORS AND INFLAMMATION MARKERS: THE RESULTS OF PROSPECTIVE COHORT STUDY

Shalnova S. A.1, Imaeva A. E.1, Kapustina A. V.1, Tyaeva E. M.1, Balanova Yu. A.1, Muromtseva G. A.1, Deev A. D.1, Shkolnikova М. А.2, Shkolnikov V. М.3

Abstract

COMPARATIVE ANALYSIS OF DIAGNOSTIC METHODS FOR SUBCLINICAL VESSELS LESION (UNDER THE COHORT OF EPIDEMIOLOGICAL STUDY ESSE-RF)

Alieva A.S.1, Boyarinova М.А.1, Orlov А.V.1, Moguchaya E.V.1, Kolesova E.P.1, Vasilyeva Е.Yu.1, Solntsev V.N.1, Rotar О.P.1,2, Konradi А. О.1,2

Abstract

COMPARATIVE ANALYSIS OF THE CALCULATION MODELS FOR ISCHEMIC HEART DISEASE OVERALL RISK IN RAILROAD WORKERS

Gorokhova S. G.1, Muraseeva E. V.1, Pfaff V. F.1, Sboev A. G.2,3, Moloshnikov I. A.2, Atkov O. Yu.1,4

Abstract

THE INFLUENCE OF ECOLOGICAL RISK FACTORS ON MORTALITY IN MOSCOW POPULATION. RISK EVALUATION AND PREDICTION

Boytsov S.A.1, Lukyanov М.М.1, Deev A.D.1, Klyashtorny V.G.1, Ivanenko А.V.2, Volkova N.S.2, Kuznetsov А.S.2, Skvortsov А. S.2, Solovyev D.V.2

Abstract

RELATION OF OXIDATIVE PARAMETERS OF LOW DENSITY LIPOPROTEIDES WITH THE AGE IN MALE POPULATION OF NOVOSIBIRSK CITY

Ragino Yu. I., Stakhneva E. M., Sadovskii E. V., Sherbakova L. V., Malyutina S. K.

Abstract

LIPOPROTEIN(A) MEANING AS AN ADDITIONAL MARKER OF CARDIOVASCULAR RISK IN PATIENTS WITH FAMILIAL HYPERCHOLESTEROLEMIA

Korneva V. A.1, Kuznetsova T. Yu.1, Tikhova G. P.2

Abstract

RELIABILITY AND VALIDITY OF RUSSIAN VERSION OF DS14 SCORE FOR ISCHEMIC HEART DISEASE PATIENTS

Pushkarev G. S., Kuznetsov V. A., Yaroslavskaya E. I., Bessonov I. S.

Abstract

ASSESSMENT OF PATIENTS COMPLIANCE FOR AMBULATORY INSTITUTIONS VISITS AND ITS INFLUENCE ON THE QUALITY OF TREATMENT BEFORE DEVELOPMENT OF ACUTE CORONARY SYNDROME, BY THE LIS-3 REGISTRY

Martsevich S. Yu.1, Semenova Yu. V.1, Kutishenko N. P.1, Zagebelniy А. А.1, Ginzburg М. L.2

Abstract

CLINIC AND PHARMACOTHERAPY

SLOW RELEASE MELATONINE IN METABOLIC SYNDROME SYMPTHOMATICS CORRECTION

Smirnova V. O., Barykina I. N., Salasyuk A. S., Khripaeva V. Yu., Palashkin R. V., Nedogoda S. V.

Abstract

ACTUAL TOPICS

EUROPEAN INITIATIVE “STENT FOR LIFE” IN RUSSIA

Ganyukov V. I.1, Protopopov A. V.2, Bashkireva A. L.1, Alekyan B. G.3, Shlyakhto E. V.4

Abstract

LITERATURE REVIEW

OBESITY AS A RISK FACTOR FOR CHRONIC NON-COMMUNICABLE DISEASES

Drapkina O. M., Eliashevich S. O., Shepel R. N.

Abstract

PRESS RELEASE

Russ J Cardiol 2016, 6 (134): 80-81, 82

RUSSIAN JOURNAL OFCARDIOLOGY, 2016, 4 (132) Engl.

Journal PDF

Cover PDF

ORIGINAL ARTICLES

CARDIOVASCULAR DISEASES AND VITAL EXHAUSTION: LONGITUDINAL STUDY IN RUSSIA/SIBERIA (WHO MONICA — PSYCHOSOCIAL PROGRAM)

Gafarov Valery, Voevoda Mikhail, Gromova Elena, Maksimov Vladimir, Gagulin Igor, Yudin Nikolay, Gafarova Almira, Mishakova Tatiana

Abstract

ASSOCIATION OF PSYCHOSOCIAL FACTORS WITH DOPAMINE RECEPTOR D4 (DRD4), DAT GENE POLYMORPHISM AND CARDIOVASCULAR INCIDENCE RISK

Gafarov Valery, Voevoda Mikhail, Gromova Elena, Maksimov Vladimir, Gagulin Igor, Yudin Nikolay, Gafarova Almira, Mishakova Tatiana

Abstract

WHO PROGRAMS: “REGISTER ACUTE MYOCARDIAL INFARCTION”, “MONICA” — DYNAMICS ACUTE CARDIOVASCULAR ACCIDENT AT YEARS 1977-2009 IN GENERAL POPULATION AGED 25-64 YEARS IN RUSSIA

Gafarov Valery, Gafarova Almira

Abstract

MYOCARDIAL INFARCTION AND STROKE: 16-YEAR RISK AND STRESS AT WORK IN OPEN POPULATION OF 25–64-YEAR-OLD WOMEN IN RUSSIA/SIBERIA (WHO MONICA–PSYCHOSOCIAL PROGRAM)

Gafarov Valery, Panov Dmitry, Gromova Elena, Gagulin Igor, Gafarova Almira

Abstract

METABOLIC AND HEMOSTATIC PARAMETERS IN PRE-DIABETES AND NEWLY DIAGNOSED TYPE 2 DIABETES

Petrik G. G.1,2, Kosmacheva Е. D.1,2, Bratchik А. V.2, Kudryashov R. О.1, Glushanova V. А.2

Abstract

INFLUENCE OF OXIDATIVE STRESS AND INFLAMMATION ON THE DEVELOPMENT OF ISCHEMIC HEART DISEASE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

Lilic J. L.1, Djindjic B. D j.1,2, Kostic T . K.2, Jovanovic A. J.3, Stanojevic D. S.2

Abstract

THE IMPACT OF INDOOR CYCLING TRAINING ON EXERCISE CAPACITY AND BLOOD LIPID PROFILE OF MEN WITH ISCHAEMIC HEART DISEASE OR AFTER MYOCARDIAL INFARCTION

Dagmara Gloc, Zbigniew Nowak

Abstract

NONLINEAR ANALYSIS OF HEART RATE DYNAMICS DURING RECOVERY FROM FLEXIBLE POLE EXERCISE INTERVENTION

Ana M. S. Antonio1, David M. Garner2, Rodrigo D. Raimundo3,4, Letícia S. de Oliveira1, Luiz Carlos de Abreu 3,4, Marcelo T . Navega5, Vitor E. Valenti1

Abstract

MULTISLICE COMPUTED TOMOGRAPHY CORONARY ANGIOGRAPHY IN PATIENTS WITH ANGINA PECTORIS

Ilić S. Dragana, Jankovic Sonja

Abstract

ACUTE EFFECTS OF AUDITORY STIMULATION WITH HEAVY METAL MUSIC ON HEART RATE RESPONSES

Marcela L. Nogueira1, Anne M. G.G. Fontes2, Luiz Carlos de Abreu3, Rodrigo D. Raimundo3, Vitor E. Valenti 1

Abstract

RENAL FUNCTION AFTER CORONARY BYPASS SURGERY IN PATIENTS WITH PRE-DIABETES

Kremneva L. V., Suplotov S. N.

Abstract

DIAGNOSTIC METHODS

ALTERNATIVE TO Q WAVE DIAGNOSIS USING CARDIAC ACTION POTENTIAL PROPAGATION TIME MEASUREMENT

Ananthi S.1, Vignesh V.1, Padmanabhan K.2

Abstract

ANGIOTENSIN II RECEPTOR TYPE 1 EXPRESSION IN PATIENTS WITH MULTIFOCAL ATHEROSCLEROSIS

Mykhailichenko I. S.

Abstract

HEART RATE TURBULENCE AS A MORTALITY PREDICTOR IN LONG-TERM STUDY IN PATIENTS WITH CORONARY HEART DISEASE

Gareeva D.1, Zagidullin N.1, Lakman I.2, Islamova R.2, Zagidullin Sh.1

Abstract

OPINION ON A PROBLEM

QUALITATIVE RESEARCH IN CARDIOLOGY: TO BE VIRTUOUS OR FAIL

Taratukhin E. O.

Abstract

LITERATURE REVIEW

ATRIAL FIBRILLATION AND RENAL DYSFUNCTION: CURRENT STATE OF THE PROBLEM AND THE PROSPECTS OF FURTHER STUDY

Protasоv K. V.1, Dorzhieva V. Z.1, Petuhova E. A.2

Abstract

CLINICAL CASE

PERSISTENT LEFT SUPERIOR VENA CAVA IN PATIENT WITH PAROXYSMAL ATRIOVENTRICULAR NODAL REENTRANT TACHYCARDIA

Agnieszka Kuczaj1, Piotr J. Stryjewski2, Andrzej R. Tomasik1, Ewa Nowalany-Kozielska1, Jadwiga Nessler3

Abstract

RUSSIAN JOURNAL OFCARDIOLOGY, 2016, 5 (133)

CLINICAL MEDICINE NEWS

Clinical medicine updates: a review of international news

Russ J Cardiol 2016, 5 (133): 6

CLINICAL GUIDELINES

2015 ESC/ERS GUIDELINES FOR THE DIAGNOSIS AND TREATMENT OF PULMONARY HYPERTENSION

The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS)

Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT)

Russ J Cardiol 2016, 5 (133): 5–64

http://dx.doi.org/10.15829/1560-4071-2016-5-5-64

Key words: guidelines, pulmonary hypertension, pulmonary arterial hypertension, chronic thromboembolic pulmonary hypertension, congenital heart disease, connective tissue disease, heart failure, respiratory, failure, endothelin receptor antagonists, phosphodiesterase type 5 inhibitors, prostacyclin analogues, lung disease, left heart disease.

2015 ESC GUIDELINES FOR THE MANAGEMENT OF INFECTIVE ENDOCARDITIS

The Task Force for the Management of Infective Endocarditis of the European Society of Cardiology (ESC)

Endorsed by: European Association for Cardio-Thoracic Surgery (EACTS), the European Association of Nuclear Medicine (EANM)

Russ J Cardiol 2016, 5 (133): 65–116

http://dx.doi.org/10.15829/1560-4071-2016-5-65-116

Key words: endocarditis, cardiac imaging, valve disease, echocardiography, prognosis, guidelines, infection, nuclear imaging, cardiac surgery, cardiac device, prosthetic heart valves, congenital heart disease, pregnancy, prophylaxis, prevention.

2015 ESC GUIDELINES FOR THE DIAGNOSIS AND MANAGEMENT OF PERICARDIAL DISEASES

The Task Force for the Management of Infective Endocarditis of the European Society of Cardiology (ESC)

Endorsed by: European Association for Cardio-Thoracic Surgery (EACTS)

Russ J Cardiol 2016, 5 (133): 117–162

http://dx.doi.org/10.15829/1560-4071-2016-5-117-162

Key words: guidelines, aetiology, constrictive pericarditis, diagnosis, myopericarditis, pericardial effusion, pericardiocentesis, pericarditis, pericardium, prognosis, tamponade, therapy.

RUSSIAN JOURNAL OF CARDIOLOGY, 2016, 4 (132)

Address to the readers

Russ J Cardiol 2016, 4 (132): 5

CLINICAL MEDICINE NEWS

Clinical medicine updates: a review of international news

Russ J Cardiol 2016, 4 (132): 6

EDITORIAL

THE CONCEPT OF NOVEL NATIONAL CLINICAL GUIDELINES ON OBESITY

Shlyakhto E. V.1, Nedogoda S. V.2, Konradi А. О.1, Baranova E. I.3, Fomin V. V.4, Vertkin А. L.5, Chumakova G. А.6

Abstract

ORIGINAL ARTICLES

A RESISTANCE TO LEPTIN IN DEVELOPMENT OF DIFFERENT OBESITY PHENOTYPES

Ott A. V.1,2, Chumakova G. A.1,3, Veselovskaya N. G.1,3

Abstract

THE INFLUENCE OF VISCERAL OBESITY ON COGNITION IN PATIENTS AFTER CORONARY ARTERY BYPASS SURGERY

Chugunova Yu. V.1,2, Chumakova G. A.1,3, Ermolin P. A.2, Baranov A. S.2

Abstract

THE “EXTRA-MEDIA” THICKNESS OF CAROTID ARTERIES AS A NOVEL MARKER OF PERIVASCULAR VISCERAL ADIPOUS TISSUE: ACCENT ON THE RELATION WITH VASCULAR REMODELLING PARAMETERS

Druzhilov M. A.1, Beteleva Yu. E.1, Khein I. V.1, Kuznetsova T. Yu.2

Abstract

SYSTEM FOR THE NEAREST CARDIOVASCULAR RISK ASSESSMENT IN SECOND TYPE DIABETES PATIENTS

Leonova N. V.1, Pushkareva S. V.2

Abstract

NON-INVASIVE ASSESSMENT OF CORONARY BLOOD FLOW IN PATIENTS WITH 2ND TYPE DIABETES DURING EXERCISE TEST

Zagatina A. V., Zhuravskaya N. T.

Abstract

REMODELING OF CEREBRAL ARTERIES IN DYSCIRCULATORY ENCEPHALOPATHY WITH ARTERIAL HYPERTENSION AND STROKE IN PATIENTS WITH RADIATION ANAMNESIS

Efremushkin G. G.1, Podsonnaya I. V.2, Belitsky S. N.2

Abstract

THE CONCERNS OF BLOOD PRESSURE MONITORING IN ARTERIAL HYPERTENSION OUTPATIENTS

Filipchenko E. M., Gorban V. V.

Abstract

THE RELATION OF ERYTHROCYTE SPHERICITY WITH MEMBRANE PROTEINS IN ARTERIAL HYPERTENSION

Sergeeva A. S.1, Pivovarov Yu. I.1, Babushkina I. V.1,2, Dmitrieva L. A.1

Abstract

MODERN METHODS OF INTRACARDIAC HEMODYNAMICS AND CARDIAC DEFORMABILITY ASSESSMENT IN PREGNANT WOMEN WITH DILATION CARDIOMYOPATHY SYNDROME

Doroshenko D. A.1, Zubarev A. R.2, Lapochkina O. B.1, Konysheva O. V.1, Tyulkina E. E.1, Volov N. A. 2

Abstract

INFLUENCE OF THE CHRONIC OBSTRUCTIVE PULMONARY DISEASE ON POST-OPERATION COURSE IN CORONARY HEART DISEASE

Klinkova A. S., Kamenskaya O. V., Karaskov A. M.

Abstract

CLINIC AND PHARMACOTHERAPY

WAYS OF MENOPAUSAL HORMONAL THERAPY IN CORRECTION OF METABOLIC DISORDERS AND ANGIOPROTECTION IN POSTMENOPAUSAL WOMEN

Khripaeva V. Yu., Barykina I. N., Salasyuk A. S., Smirnova V. O., Palashkin R. V., Nedogoda S. V.

Abstract

INFLUENCE OF COMBINATION ANTIHYPERTENSION THERAPY ON THE PARAMETERS OF VESSEL WALL RIGIDITY IN NON-CONTROLLED ARTERIAL HYPERTENSION PATIENTS WITH DEPRESSION

Skibitsky V. V., Skibitsky A. V., Fendrikova A. V.

Abstract

CLINICAL CASE OF USAGE OF SERELAXIN IN THE PATIENT WITH ACUTE DECOMPENSATED HEART FAILURE

Zhirov I. V., Nasonova S. N., Tereshchenko S. N., Nikolaeva O. A., Uskach T. M.

Abstract

SUPPORTING A PRACTITIONER

METHODS OF VISCERAL OBESITY ASSESSMENT IN CLINICAL PRACTICE

Chumakova G. A.1,3, Veselovskaya N. G.2,3

Abstract

OPINION ON A PROBLEM

HYPERVISCOSITY SYNDROME IN ARTERIAL HYPERTENSION AND HEMORHEOLOGICAL EFFECTS OF ANTIHYPERTENSIVE DRUGS

Shamanaev A. Yu., Aliev O. I., Anishchenko A. M., Sidekhmenova A. V., Plotnikov M. B.

Abstract

CLINICAL CASE

THE CASE OF SUCCESSFUL COMPENSATION AFTER TACHICARDIC CARDIOMYOPATHY

Kudinova M. A.1,2, Vaslyaeva S. N.1, Gorbatov E. A.1, Benevskaya M. A.2, Taratukhin E. O.2

Abstract

INFORMATION

Russ J Cardiol 2016, 4 (132):107-109

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